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  • ATAC-seq測序與分析

    染色質開放性是指真核生物染色質和組蛋白、轉錄因子等是否結合的開放程度,這一特性與染色質轉錄活躍程度相關,從而能夠揭示基因調控的機制。ATAC-seq測序與分析,即利用轉座酶研究染色質可接近性的高通量測序,可以檢測染色質開放區域,其原理是通過轉座酶Tn5容易結合在開放染色質區域的特性,對Tn5酶捕獲到的DNA序列進行測序和富集分析。

    更新時間:2021-09-16
    產品型號:
    瀏覽量:1239
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  • ChIP-Seq測序與分析

    ChIP-Seq測序與分析 是指通過染色質免疫共沉淀技術特異性地富集目的蛋白結合的DNA片段,并對其進行純化和文庫構建;然后對富集得到的DNA片段進行高通量測序,通過將獲得的數百萬條序列標簽精確定位到基因組上,從而獲得全基因組范圍內與組蛋白、轉錄因子等互作的 DNA 區段信息,是目前在全基因組水平研究蛋白結合靶DNA序列的重要手段,為轉錄因子、組蛋白修飾、核小體定位等表觀遺傳學的研究提供有效方法。

    更新時間:2021-09-16
    產品型號:
    瀏覽量:1199
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